The GENERATE Network structure

The GErman NEtwork for Research on AuToimmune Encephalitis is comprised of individual inter-disciplinary groups of experts working in basic and clinical research, linked by a central national patient register.

The primary objective of the network is to improve the diagnosis, therapy and care of patients with autoimmune encephalitis. GENERATE assumes that there are numerous additional, previously unknown target antigens in patients with autoimmune encephalitis. Moreover, the underlying pathophysiology and pathogenesis of the related disorders have only been rudimentarily elucidated thus far. To further improve early detection and evolve the most specific treatment modalities, the GENERATE Network fosters tight cross-disciplinary collaboration and utilizes the numerous overlaps within the groups working on basic research and clinical practice at the participating centers. The goal is to ensure that new evidence relating to diagnostic and therapeutic methods can be optimally fast-tracked.

In the following, you will find brief descriptions of the research projects pursued by the individual clinical and basic research working groups.

Centers

Find a center near you here.

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References

Peer M, Prüss H, Ben-Dayan I, Paul F, Arzy S, Finke C.
Lancet Psychiatry. 2017 Oct;4(10):768-774. doi: 10.1016/S2215-0366(17)30330-9. Epub 2017 Sep 4.
PMID: 28882707
Link: https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30330-9/fulltext

Heine J, Prüss H, Kopp UA, Wegner F, Then Bergh F, Münte T, Wandinger KP, Paul F, Bartsch T, Finke C.
J Neurol Neurosurg Psychiatry. 2018 Nov;89(11):1191-1199. doi: 10.1136/jnnp-2017-317780. Epub 2018 Jun 9.
PMID: 29886429
Link: https://jnnp.bmj.com/content/89/11/1191

Autoantibody-mediated encephalitis - differential diagnosis in patients with impaired consciousness of unclear origin

Wandinger, Klaus-Peter; Leypoldt, Frank; Junker, Ralf
Dtsch Arztebl Int 2018; 115(40): 666-73; DOI: 10.3238/arztebl.2018.0666
Link: https://www.aerzteblatt.de/archiv/201062/Autoantikoerper-vermittelte-Enzephalitiden

Dalmau J, Graus F.
N Engl J Med. 2018 Mar 1;378(9):840-851. doi: 10.1056/NEJMra1708712. Review. No abstract available.
PMID: 29490181
Link: https://www.nejm.org/doi/full/10.1056/NEJMra1708712

Mueller SH, Färber A, Prüss H, Melzer N, Golombeck KS, Kümpfel T, Thaler F, Elisak M, Lewerenz J, Kaufmann M, Sühs KW, Ringelstein M, Kellinghaus C, Bien CG, Kraft A, Zettl UK, Ehrlich S, Handreka R, Rostásy K, Then Bergh F, Faiss JH, Lieb W, Franke A, Kuhlenbäumer G, Wandinger KP, LeypoldtF; German Network for Research on Autoimmune Encephalitis (GENERATE).
Ann Neurol. 2018 Apr;83(4):863-869. doi: 10.1002/ana.25216.
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25216

Malviya M, Barman S, Golombeck KS, Planagumà J, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, Wandinger KP, Martín-García E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung HP, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N.
Ann Clin Transl Neurol. 2017 Oct 3;4(11):768-783. doi: 10.1002/acn3.444. eCollection 2017 Nov.
PMID: 29159189
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682115/