Dear Website Visitors, dear Patients and Colleagues,

Welcome to the GENERATE homepage! GENERATE stands for GErman NEtwork for Research on AuToimmune Encephalitis. Our mission is to address the medical community working on autoimmune encephalitis as well as all patients and their relatives touched by this condition. The website is designed to compile and disseminate information on the various types of autoimmune encephalitis:

  • Anti-NMDA receptor antibody encephalitis
  • Encephalomyelitis
  • Limbic encephalitis
  • Brainstem encephalitis
  • Cerebellitis
  • Myelitis
  • Stiff person syndrome (SPS) and stiff person syndrome plus, e.g. progressive encephalomyelitis with rigidity and myoclonus (PERM), hyperekplexia (startle disease)
  • Morvan syndrome and acquired neuromyotonia (Isaacs' syndrome)

Autoantibodies can be demonstrated in many of these syndromes. These include autoantibodies against NMDAR, LgI1, CASPR2, GAD, GABA(b)R, AMPAR, GlyR, DPPX, D2R, MOG. The GENERATE network is committed to educating the medical and patient communities about syndromes with known antibodies as well as about “seronegative” syndromes, while driving the search for new target antigens.

The goal of this initiative is to ensure the best-in-class care of patients suffering from this rare disease by promoting autoimmune encephalitis-related education, research and therapy.

By bundling the knowledge and experience of all stakeholders, we can succeed in getting those affected rapid access to the necessary treatments and enable them to liaise with specialist centers.

The GENERATE homepage provides information about these diseases and makes it easy to find the appropriate specialized centers. It additionally posts evidence and references on pathophysiology, diagnostics and therapy.

 

Anti-NMDAR antibodies (green) on a hippocampal neuron (red). DAPI-stained nucleus (blue).

Centers

Find a center near you here.

Latest news

Upcoming events

Der Forschungsverbund CONNECT‐GENERATE – als Teil des bestehenden GENERATE‐Netzwerks – wird seit 2019 durch das Bundesministerium für Bildung und Forschung (BMBF) gefördert. Nun ist der Forschungsverbund auch Teil des Forschungsnetzwerks Research for Rare geworden, dessen Ziel es ist, durch Grundlagen‐ und Therapieforschung die Diagnostik seltener Erkrankungen zu beschleunigen und den Betroffenen zügig eine adäquate Behandlung zu ermöglichen. CONNECT-GENERATE wird in den aktuellen Research for Rare - Newsletter vorgestellt. Mit gegenwärtig über 100 Zentren im GENERATE‐Netzwerk, arbeiten wir an der Umsetzung unserer gemeinsamen klinisch‐wissenschaftlichen Ziele und freuen uns sehr, Teil dieser wertvollen Initiative zu sein!

https://www.research4rare.de/
https://www.research4rare.de/forschungsverbuende/connect-generate/

Berlin, Germany

13th GENERATE e.V. - network meeting 2020 in Berlin as part of the 93th Congress of the German Society of Neurology 4.-7. November in Berlin. This year there will also be a 90min symposium entitled: "GENERATE 2020: Controversies in the Diagnosis and Therapy of Autoimmune Encephalitides" on Friday, November 6th, 2020, 3.00 pm to 4.30 pm in the "Helsinki" room.

References

Peer M, Prüss H, Ben-Dayan I, Paul F, Arzy S, Finke C.
Lancet Psychiatry. 2017 Oct;4(10):768-774. doi: 10.1016/S2215-0366(17)30330-9. Epub 2017 Sep 4.
PMID: 28882707
Link: https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30330-9/fulltext

Heine J, Prüss H, Kopp UA, Wegner F, Then Bergh F, Münte T, Wandinger KP, Paul F, Bartsch T, Finke C.
J Neurol Neurosurg Psychiatry. 2018 Nov;89(11):1191-1199. doi: 10.1136/jnnp-2017-317780. Epub 2018 Jun 9.
PMID: 29886429
Link: https://jnnp.bmj.com/content/89/11/1191

Autoantibody-mediated encephalitis - differential diagnosis in patients with impaired consciousness of unclear origin

Wandinger, Klaus-Peter; Leypoldt, Frank; Junker, Ralf
Dtsch Arztebl Int 2018; 115(40): 666-73; DOI: 10.3238/arztebl.2018.0666
Link: https://www.aerzteblatt.de/archiv/201062/Autoantikoerper-vermittelte-Enzephalitiden

Dalmau J, Graus F.
N Engl J Med. 2018 Mar 1;378(9):840-851. doi: 10.1056/NEJMra1708712. Review. No abstract available.
PMID: 29490181
Link: https://www.nejm.org/doi/full/10.1056/NEJMra1708712

Mueller SH, Färber A, Prüss H, Melzer N, Golombeck KS, Kümpfel T, Thaler F, Elisak M, Lewerenz J, Kaufmann M, Sühs KW, Ringelstein M, Kellinghaus C, Bien CG, Kraft A, Zettl UK, Ehrlich S, Handreka R, Rostásy K, Then Bergh F, Faiss JH, Lieb W, Franke A, Kuhlenbäumer G, Wandinger KP, LeypoldtF; German Network for Research on Autoimmune Encephalitis (GENERATE).
Ann Neurol. 2018 Apr;83(4):863-869. doi: 10.1002/ana.25216.
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25216

Malviya M, Barman S, Golombeck KS, Planagumà J, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, Wandinger KP, Martín-García E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung HP, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N.
Ann Clin Transl Neurol. 2017 Oct 3;4(11):768-783. doi: 10.1002/acn3.444. eCollection 2017 Nov.
PMID: 29159189
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682115/