Dear Website Visitors, dear Patients and Colleagues,

Welcome to the GENERATE homepage! GENERATE stands for GErman NEtwork for Research on AuToimmune Encephalitis. Our mission is to address the medical community working on autoimmune encephalitis as well as all patients and their relatives touched by this condition. The website is designed to compile and disseminate information on the various types of autoimmune encephalitis:

  • Anti-NMDA receptor antibody encephalitis
  • Encephalomyelitis
  • Limbic encephalitis
  • Brainstem encephalitis
  • Cerebellitis
  • Myelitis
  • Stiff person syndrome (SPS) and stiff person syndrome plus, e.g. progressive encephalomyelitis with rigidity and myoclonus (PERM), hyperekplexia (startle disease)
  • Morvan syndrome and acquired neuromyotonia (Isaacs' syndrome)

Autoantibodies can be demonstrated in many of these syndromes. These include autoantibodies against NMDAR, LgI1, CASPR2, GAD, GABA(b)R, AMPAR, GlyR, DPPX, D2R, MOG. The GENERATE network is committed to educating the medical and patient communities about syndromes with known antibodies as well as about “seronegative” syndromes, while driving the search for new target antigens.

The goal of this initiative is to ensure the best-in-class care of patients suffering from this rare disease by promoting autoimmune encephalitis-related education, research and therapy.

By bundling the knowledge and experience of all stakeholders, we can succeed in getting those affected rapid access to the necessary treatments and enable them to liaise with specialist centers.

The GENERATE homepage provides information about these diseases and makes it easy to find the appropriate specialized centers. It additionally posts evidence and references on pathophysiology, diagnostics and therapy.

 

Anti-NMDAR antibodies (green) on a hippocampal neuron (red). DAPI-stained nucleus (blue).

Centers

Find a center near you here.

Latest news

GENERATE-Patient*innenforum

GENERATE läd Betroffene und Angehörige am 06. Juli 2024 zum gemeinsamen Webinar ein.

NEMOS Patiententag 2023 in Frankfurt am Main

NEMOS läd Betroffene sowie Angehörige am 19.10.2023 zum Patiententag ein: nemos-net.de

Sechste Fallkonferenz GENERATE & NEMOS

Thema: Patienten mit AQP4-IgG-positiver NMOSD und Neudiagnose einer malignen hämatologischen Erkrankung unter Immuntherapie mit Azathioprin.

Montag, den 22.05.2023, 14:00 Uhr.

Upcoming events

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References

Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis.

Gallus M, Roll W, Dik A, Barca C, Zinnhardt B, Hicking G, Mueller C, Naik VN, Anstötz M, Krämer J, Rolfes L, Wachsmuth L, Pitsch J, van Loo KMJ, Räuber S, Okada H, Wimberley C, Strippel C, Golombeck KS, Johnen A, Kovac S, Groß CC, Backhaus P, Seifert R, Lewerenz J, Surges R, Elger CE, Wiendl H, Ruck T, Becker AJ, Faber C, Jacobs AH, Bauer J, Meuth SG, Schäfers M, Melzer N. Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis. Sci Adv. 2023 Jun 9;9(23):eabq7595. doi: 10.1126/sciadv. abq7595. Epub 2023 Jun 9. PMID: 37294768; PMCID: PMC10256169.

Crebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis.

Räuber S, Schroeter CB, Strippel C, Nelke C, Ruland T, Dik A, Golombeck KS, Regner-Nelke L, Paunovic M, Esser D, Münch C, Rosenow F, van Duijn M, Henes A, Ruck T, Amit I, Leypoldt F, Titulaer MJ, Wiendl H, Meuth SG, Meyer Zu Hörste G, Melzer N. Cerebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis. J Autoimmun. 2023 Feb;135:102985. doi: 10.1016/j.jaut.2022.102985. Epub 2023 Jan 6. PMID: 36621173.

Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis

Brändle SM, Cerina M, Weber S et al. PNAS March 2, 2021 118 (9) e1916337118.

Dieses Paper wurde vom Research4Rare Verbund zum Paper of the Month gewählt und erscheint im April dieses Jahres im BMBF Newsletter!

A Therapeutic Non-self-reactive
SARS-CoV-2 Antibody
Protects from Lung Pathology
in a COVID-19 Hamster Model

Kreye J, Momsen Reincke S, Kornau HC et al.
Cell. 2020 Nov 12;183(4):1058-1069.e19.

CD8+ T-Lymphocyte–Driven Limbic
Encephalitis Results in Temporal Lobe
Epilepsy

Pitsch J, van Loo KMJ, Gallus M et al.
Ann Neurol. 2021; 00:1-20.

Low CSF CD4/CD8+ T-cell proportions are associated with blood-CSF barrier dysfunction in limbic encephalitis.

Hansen N, Schwing K, Önder D, et al. Epilepsy Behav. 2020;102:106682.



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