About the Network

The mission of the GErman NEtwork for Research on AuToimmune Encephalitis (GENERATE) is to empower cooperation between centers with clinical and scientific expertise. GENERATE we will enable us to better characterize the immunopathogenesis and neuropathophysiology of the different autoimmune encephalitides while elucidating the clinical particulars, clinical courses and treatment strategies. Owing to the rare occurrence of autoimmune encephalitis and other autoimmune inflammations of the brain, new evidence on incidences, clinical symptoms, risks, prognostic factors and efficacious treatments can only be amassed by collecting data on large numbers of cases.

The members of the Network pursue the following mutual clinical and scientific objectives:

  • Setting up a joint patient register to standardize clinical data collection
  • Building a biobank with cells, blood & CSF for later analysis
  • Creating a joint brain biopsy database
  • Evaluating the pathogenicity of antineuronal antibodies
  • Developing diagnostic and therapeutic standards and assessing national and international treatment recommendations
  • Providing help in therapeutic decision-making, directing affected individuals and their relatives to qualified counseling services
  • Conducting prospective studies on the therapy and clinical course of autoimmune encephalitis
  • Liaison work between patients interested in clinical trials and the competent centers (e.g. MRI, therapy or prognosis studies)

Dear Colleagues,
Please take part in the initiative…

The Network cannot achieve its mission unless its many stakeholders work collaboratively. Therefore, we call upon all interested members of the medical community to impart to us their own experiences with their patients.

If you would like your center to participate in the clinical trials task force, don't hesitate to contact us by email at: info@generate-net.de or by using the contact form.


Find a center near you here.

Latest news

Upcoming events

Der Forschungsverbund CONNECT‐GENERATE – als Teil des bestehenden GENERATE‐Netzwerks – wird seit 2019 durch das Bundesministerium für Bildung und Forschung (BMBF) gefördert. Nun ist der Forschungsverbund auch Teil des Forschungsnetzwerks Research for Rare geworden, dessen Ziel es ist, durch Grundlagen‐ und Therapieforschung die Diagnostik seltener Erkrankungen zu beschleunigen und den Betroffenen zügig eine adäquate Behandlung zu ermöglichen. CONNECT-GENERATE wird in den aktuellen Research for Rare - Newsletter vorgestellt. Mit gegenwärtig über 100 Zentren im GENERATE‐Netzwerk, arbeiten wir an der Umsetzung unserer gemeinsamen klinisch‐wissenschaftlichen Ziele und freuen uns sehr, Teil dieser wertvollen Initiative zu sein!


Berlin, Germany

13th GENERATE e.V. - network meeting 2020 in Berlin as part of the 93th Congress of the German Society of Neurology 4.-7. November in Berlin. This year there will also be a 90min symposium entitled: "GENERATE 2020: Controversies in the Diagnosis and Therapy of Autoimmune Encephalitides" on Friday, November 6th, 2020, 3.00 pm to 4.30 pm in the "Helsinki" room.


Peer M, Prüss H, Ben-Dayan I, Paul F, Arzy S, Finke C.
Lancet Psychiatry. 2017 Oct;4(10):768-774. doi: 10.1016/S2215-0366(17)30330-9. Epub 2017 Sep 4.
PMID: 28882707
Link: https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30330-9/fulltext

Heine J, Prüss H, Kopp UA, Wegner F, Then Bergh F, Münte T, Wandinger KP, Paul F, Bartsch T, Finke C.
J Neurol Neurosurg Psychiatry. 2018 Nov;89(11):1191-1199. doi: 10.1136/jnnp-2017-317780. Epub 2018 Jun 9.
PMID: 29886429
Link: https://jnnp.bmj.com/content/89/11/1191

Autoantibody-mediated encephalitis - differential diagnosis in patients with impaired consciousness of unclear origin

Wandinger, Klaus-Peter; Leypoldt, Frank; Junker, Ralf
Dtsch Arztebl Int 2018; 115(40): 666-73; DOI: 10.3238/arztebl.2018.0666
Link: https://www.aerzteblatt.de/archiv/201062/Autoantikoerper-vermittelte-Enzephalitiden

Dalmau J, Graus F.
N Engl J Med. 2018 Mar 1;378(9):840-851. doi: 10.1056/NEJMra1708712. Review. No abstract available.
PMID: 29490181
Link: https://www.nejm.org/doi/full/10.1056/NEJMra1708712

Mueller SH, Färber A, Prüss H, Melzer N, Golombeck KS, Kümpfel T, Thaler F, Elisak M, Lewerenz J, Kaufmann M, Sühs KW, Ringelstein M, Kellinghaus C, Bien CG, Kraft A, Zettl UK, Ehrlich S, Handreka R, Rostásy K, Then Bergh F, Faiss JH, Lieb W, Franke A, Kuhlenbäumer G, Wandinger KP, LeypoldtF; German Network for Research on Autoimmune Encephalitis (GENERATE).
Ann Neurol. 2018 Apr;83(4):863-869. doi: 10.1002/ana.25216.
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25216

Malviya M, Barman S, Golombeck KS, Planagumà J, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, Wandinger KP, Martín-García E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung HP, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N.
Ann Clin Transl Neurol. 2017 Oct 3;4(11):768-783. doi: 10.1002/acn3.444. eCollection 2017 Nov.
PMID: 29159189
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682115/