About the Network

The mission of the GErman NEtwork for Research on AuToimmune Encephalitis (GENERATE) is to empower cooperation between centers with clinical and scientific expertise. GENERATE we will enable us to better characterize the immunopathogenesis and neuropathophysiology of the different autoimmune encephalitides while elucidating the clinical particulars, clinical courses and treatment strategies. Owing to the rare occurrence of autoimmune encephalitis and other autoimmune inflammations of the brain, new evidence on incidences, clinical symptoms, risks, prognostic factors and efficacious treatments can only be amassed by collecting data on large numbers of cases.

The members of the Network pursue the following mutual clinical and scientific objectives:

  • Setting up a joint patient register to standardize clinical data collection
  • Building a biobank with cells, blood & CSF for later analysis
  • Creating a joint brain biopsy database
  • Evaluating the pathogenicity of antineuronal antibodies
  • Developing diagnostic and therapeutic standards and assessing national and international treatment recommendations
  • Providing help in therapeutic decision-making, directing affected individuals and their relatives to qualified counseling services
  • Conducting prospective studies on the therapy and clinical course of autoimmune encephalitis
  • Liaison work between patients interested in clinical trials and the competent centers (e.g. MRI, therapy or prognosis studies)

Dear Colleagues,
Please take part in the initiative…

The Network cannot achieve its mission unless its many stakeholders work collaboratively. Therefore, we call upon all interested members of the medical community to impart to us their own experiences with their patients.

If you would like your center to participate in the clinical trials task force, don't hesitate to contact us by email at: info@generate-net.de or by using the contact form.


Find a center near you here.

Latest news

Upcoming events

GENERATE-Patientenforum anlässlich des Welt-Enzephalitis-Tages 2021


Der GENERATE e.V. plant anlässlich des Welt-Enzephalitis-Tages am 22.2.2021 (Montag) um 16.00 Uhr ein Patientenforum. Die Veranstaltung soll als Webinar stattfinden und richtet sich an Patientinnen und Patienten mit Autoimmun-Enzephalitis sowie deren Angehörigen. Hier können Betroffene sich über Neues aus Diagnostik und Therapie sowie über die Gründung einer Selbsthilfegruppe für Autoimmun-Enzephalitis informieren.


Hansen N, Schwing K, Önder D, et al. Epilepsy Behav. 2020;102:106682.

Bracher A, Alcalá C, Ferrer J, et al. Ann Clin Transl Neurol. 2020;7(2):239‐244.

Bien CG, Bien CI, Dogan Onugoren M, et al. [published online ahead of print, 2020 Apr 3] [published correction appears in J Neurol. 2020 May 12;:]. J Neurol. 2020;10.1007/s00415-020-09814-3.

Kornau HC, Kreye J, Stumpf A, et al. Ann Neurol. 2020;87(3):405‐418

Steiner J, Prüss H, Köhler S, Frodl T, Hasan A, Falkai P. World J Biol Psychiatry. 2020;21(4):241‐254.