GENERATE SOPs

The GENERATE network drafts standard operational procedures for diagnostics and therapy of patients with autoimmune encephalitis in Germany. Ultimate goal in harmonising procedures is to improve patient care and facilitate scientific analysis of data. These SOPs are being drafted by designated members of the GENERATE network, circulated with all members and published online.

SOP Standard imaging in autoimmune encephalitis version 1 15-02-2016

SOP Standard neuropsychoilogical diagnostics in autoimmune encephalitis version 1 22-02-2016

SOP vaccination recommendation (SARS-CoV-2) of the GENERATE network version 1 from 07-05-2021 (123.3 KiB)

SOP´s RE-GENERATE:

SOP 01 Serum aus Vollblut Version1 vom 04.01.2021

SOP 02 EDTA-Plasma Version 1 vom 04.01.2021

SOP 03 PBMC aus EDTA Vollblut Version 1 vom 04.01.2021

SOP 04 Zellfreier Liquor Version 1 vom 04.01.2021

SOP 05 Liquorzellen Version 1 vom 04.01.2021

Further SOPs are being drafted.

Centers

Find a center near you here.

Latest news

Sechste Fallkonferenz GENERATE & NEMOS

Thema: Patienten mit AQP4-IgG-positiver NMOSD und Neudiagnose einer malignen hämatologischen Erkrankung unter Immuntherapie mit Azathioprin.

Montag, den 22.05.2023, 14:00 Uhr.

15. GENERATE e.V. Netzwerktreffen im Rahmen der DGN 2022

Mittwoch, den 02.11.2022, von 18.00 bis 19.30 Uhr im CityCube Berlin

SYNAPS & CONNECT-GENERATE Symposium 2022

June 26th to 29th 2022 | Tutzing, Germany

application/pdf Programm_SYNABS.pdf (3.4 MiB)

Upcoming events

Currently there are no events.

References

Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis.

Gallus M, Roll W, Dik A, Barca C, Zinnhardt B, Hicking G, Mueller C, Naik VN, Anstötz M, Krämer J, Rolfes L, Wachsmuth L, Pitsch J, van Loo KMJ, Räuber S, Okada H, Wimberley C, Strippel C, Golombeck KS, Johnen A, Kovac S, Groß CC, Backhaus P, Seifert R, Lewerenz J, Surges R, Elger CE, Wiendl H, Ruck T, Becker AJ, Faber C, Jacobs AH, Bauer J, Meuth SG, Schäfers M, Melzer N. Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis. Sci Adv. 2023 Jun 9;9(23):eabq7595. doi: 10.1126/sciadv. abq7595. Epub 2023 Jun 9. PMID: 37294768; PMCID: PMC10256169.

Crebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis.

Räuber S, Schroeter CB, Strippel C, Nelke C, Ruland T, Dik A, Golombeck KS, Regner-Nelke L, Paunovic M, Esser D, Münch C, Rosenow F, van Duijn M, Henes A, Ruck T, Amit I, Leypoldt F, Titulaer MJ, Wiendl H, Meuth SG, Meyer Zu Hörste G, Melzer N. Cerebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis. J Autoimmun. 2023 Feb;135:102985. doi: 10.1016/j.jaut.2022.102985. Epub 2023 Jan 6. PMID: 36621173.

Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis

Brändle SM, Cerina M, Weber S et al. PNAS March 2, 2021 118 (9) e1916337118.

Dieses Paper wurde vom Research4Rare Verbund zum Paper of the Month gewählt und erscheint im April dieses Jahres im BMBF Newsletter!

A Therapeutic Non-self-reactive
SARS-CoV-2 Antibody
Protects from Lung Pathology
in a COVID-19 Hamster Model

Kreye J, Momsen Reincke S, Kornau HC et al.
Cell. 2020 Nov 12;183(4):1058-1069.e19.

CD8+ T-Lymphocyte–Driven Limbic
Encephalitis Results in Temporal Lobe
Epilepsy

Pitsch J, van Loo KMJ, Gallus M et al.
Ann Neurol. 2021; 00:1-20.

Low CSF CD4/CD8+ T-cell proportions are associated with blood-CSF barrier dysfunction in limbic encephalitis.

Hansen N, Schwing K, Önder D, et al. Epilepsy Behav. 2020;102:106682.



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