GENERATE SOPs

The GENERATE network drafts standard operational procedures for diagnostics and therapy of patients with autoimmune encephalitis in Germany. Ultimate goal in harmonising procedures is to improve patient care and facilitate scientific analysis of data. These SOPs are being drafted by designated members of the GENERATE network, circulated with all members and published online.

SOP Standard imaging in autoimmune encephalitis version 1 15-02-2016

SOP Standard neuropsychoilogical diagnostics in autoimmune encephalitis version 1 22-02-2016

SOP vaccination recommendation (SARS-CoV-2) of the GENERATE network version 1 from 07-05-2021

SOP´s RE-GENERATE:

SOP 01 Serum aus Vollblut Version1 vom 04.01.2021

SOP 02 EDTA-Plasma Version 1 vom 04.01.2021

SOP 03 PBMC aus EDTA Vollblut Version 2 vom 09.04.2024

SOP 04 Zellfreier Liquor Version 1 vom 04.01.2021

SOP 05 Liquorzellen Version 1 vom 04.01.2021

Further SOPs are being drafted.

Centers

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Latest news

NEMOS Patient:innentag 2025

Datum: 01.10.2025
Tagungsort und Hotel: Sportschule und Bildungsstätte, Frankfurt am Main

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DGN-SPECIAL Neuroimmunologie Summer Academy präsentiert von den Netzwerken GENERATE und NEMOS 08.-09. Sept. 2025

In der Evangelischen Akademie Frankfurt und im Hybridformat werden wir aktuelle Erkenntnisse zu autoimmunen Enzephalitiden, paraneoplastischen Syndromen, MOG-Antikörper-assoziierten Erkrankungen (MOGAD), Neuromyelitis optica Spektrumserkrankungen (NMOSD) und myasthenen Syndromen vermitteln.

zur Einladung

GENERATE e.V. is nominated for the International Life Sciences Awards 2024


References

Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis.

Gallus M, Roll W, Dik A, Barca C, Zinnhardt B, Hicking G, Mueller C, Naik VN, Anstötz M, Krämer J, Rolfes L, Wachsmuth L, Pitsch J, van Loo KMJ, Räuber S, Okada H, Wimberley C, Strippel C, Golombeck KS, Johnen A, Kovac S, Groß CC, Backhaus P, Seifert R, Lewerenz J, Surges R, Elger CE, Wiendl H, Ruck T, Becker AJ, Faber C, Jacobs AH, Bauer J, Meuth SG, Schäfers M, Melzer N. Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis. Sci Adv. 2023 Jun 9;9(23):eabq7595. doi: 10.1126/sciadv. abq7595. Epub 2023 Jun 9. PMID: 37294768; PMCID: PMC10256169.

Crebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis.

Räuber S, Schroeter CB, Strippel C, Nelke C, Ruland T, Dik A, Golombeck KS, Regner-Nelke L, Paunovic M, Esser D, Münch C, Rosenow F, van Duijn M, Henes A, Ruck T, Amit I, Leypoldt F, Titulaer MJ, Wiendl H, Meuth SG, Meyer Zu Hörste G, Melzer N. Cerebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis. J Autoimmun. 2023 Feb;135:102985. doi: 10.1016/j.jaut.2022.102985. Epub 2023 Jan 6. PMID: 36621173.

Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis

Brändle SM, Cerina M, Weber S et al. PNAS March 2, 2021 118 (9) e1916337118.

Dieses Paper wurde vom Research4Rare Verbund zum Paper of the Month gewählt und erscheint im April dieses Jahres im BMBF Newsletter!

A Therapeutic Non-self-reactive
SARS-CoV-2 Antibody
Protects from Lung Pathology
in a COVID-19 Hamster Model

Kreye J, Momsen Reincke S, Kornau HC et al.
Cell. 2020 Nov 12;183(4):1058-1069.e19.

CD8+ T-Lymphocyte–Driven Limbic
Encephalitis Results in Temporal Lobe
Epilepsy

Pitsch J, van Loo KMJ, Gallus M et al.
Ann Neurol. 2021; 00:1-20.

Low CSF CD4/CD8+ T-cell proportions are associated with blood-CSF barrier dysfunction in limbic encephalitis.

Hansen N, Schwing K, Önder D, et al. Epilepsy Behav. 2020;102:106682.



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