Dear Website Visitors, dear Patients and Colleagues,

Welcome to the GENERATE homepage! GENERATE stands for GErman NEtwork for Research on AuToimmune Encephalitis. Our mission is to address the medical community working on autoimmune encephalitis as well as all patients and their relatives touched by this condition. The website is designed to compile and disseminate information on the various types of autoimmune encephalitis:

  • Anti-NMDA receptor antibody encephalitis
  • Encephalomyelitis
  • Limbic encephalitis
  • Brainstem encephalitis
  • Cerebellitis
  • Myelitis
  • Stiff person syndrome (SPS) and stiff person syndrome plus, e.g. progressive encephalomyelitis with rigidity and myoclonus (PERM), hyperekplexia (startle disease)
  • Morvan syndrome and acquired neuromyotonia (Isaacs' syndrome)

Autoantibodies can be demonstrated in many of these syndromes. These include autoantibodies against NMDAR, LgI1, CASPR2, GAD, GABA(b)R, AMPAR, GlyR, DPPX, D2R, MOG. The GENERATE network is committed to educating the medical and patient communities about syndromes with known antibodies as well as about “seronegative” syndromes, while driving the search for new target antigens.

The goal of this initiative is to ensure the best-in-class care of patients suffering from this rare disease by promoting autoimmune encephalitis-related education, research and therapy.

By bundling the knowledge and experience of all stakeholders, we can succeed in getting those affected rapid access to the necessary treatments and enable them to liaise with specialist centers.

The GENERATE homepage provides information about these diseases and makes it easy to find the appropriate specialized centers. It additionally posts evidence and references on pathophysiology, diagnostics and therapy.

 

Anti-NMDAR antibodies (green) on a hippocampal neuron (red). DAPI-stained nucleus (blue).

Centers

Find a center near you here.

Latest news

15. GENERATE e.V. Netzwerktreffen im Rahmen der DGN 2022

Mittwoch, den 02.11.2022, von 18.00 bis 19.30 Uhr im CityCube Berlin

SYNAPS & CONNECT-GENERATE Symposium 2022

June 26th to 29th 2022 | Tutzing, Germany

GENERATE-Netzwerk Patientenforum am 23. Mai 2022 von 17.00 bis 19.00 Uhr (Webinar)

Upcoming events

15. GENERATE e.V. Netzwerktreffen im Rahmen der DGN 2022

Uhr

CityCube Berlin

References

Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis

Brändle SM, Cerina M, Weber S et al. PNAS March 2, 2021 118 (9) e1916337118.

Dieses Paper wurde vom Research4Rare Verbund zum Paper of the Month gewählt und erscheint im April dieses Jahres im BMBF Newsletter!

A Therapeutic Non-self-reactive
SARS-CoV-2 Antibody
Protects from Lung Pathology
in a COVID-19 Hamster Model

Kreye J, Momsen Reincke S, Kornau HC et al.
Cell. 2020 Nov 12;183(4):1058-1069.e19.

CD8+ T-Lymphocyte–Driven Limbic
Encephalitis Results in Temporal Lobe
Epilepsy

Pitsch J, van Loo KMJ, Gallus M et al.
Ann Neurol. 2021; 00:1-20.

Low CSF CD4/CD8+ T-cell proportions are associated with blood-CSF barrier dysfunction in limbic encephalitis.

Hansen N, Schwing K, Önder D, et al. Epilepsy Behav. 2020;102:106682.

An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis.

Bracher A, Alcalá C, Ferrer J, et al. Ann Clin Transl Neurol. 2020;7(2):239‐244.

Routine diagnostics for neural antibodies, clinical correlates, treatment and functional outcome

Bien CG, Bien CI, Dogan Onugoren M, et al. [published online ahead of print, 2020 Apr 3] [published correction appears in J Neurol. 2020 May 12;:]. J Neurol. 2020;10.1007/s00415-020-09814-3.